Survival in progressive systemic sclerosis with pulmonary involvement: a single-center experience in Istanbul, Turkey
Identifieur interne : 001505 ( Main/Exploration ); précédent : 001504; suivant : 001506Survival in progressive systemic sclerosis with pulmonary involvement: a single-center experience in Istanbul, Turkey
Auteurs : Ferit Zuhur [Turquie] ; Sayid Shafi Zuhur [Turquie] ; Cigdem Zuhur [Turquie] ; Benan Musellim [Turquie] ; Gul Ongen [Turquie]Source :
- Rheumatology International [ 0172-8172 ] ; 2012-06-01.
English descriptors
- KwdEn :
Abstract
Abstract: The objective of the current study was to determine survival and factors that affect survival in progressive systemic sclerosis (SSc) with pulmonary involvement. A total of 102 SSc patients with pulmonary involvement, diagnosed between 1994 and 2008, enrolled into the study. Pulmonary involvement was defined based on the presence of interstitial changes on high-resolution CT (HRCT). Demographical, clinical, radiological, and laboratory data of the patients were found from patient records and were used for the evaluation of survival. The mean age of the patients at diagnosis was 50 ± 12 years. In follow-up, 22 (21.5%) patients were deceased. The mean age of the patients at death was 55 ± 12 years. Seventy-eight percent of known causes of mortality were related to pulmonary complications. After any initial systemic manifestation of disease, the mean survival was 447 ± 27 months and 5, 10, 15, and 20 year survival rates were 99, 92, 83, and 72%, respectively. The mean survival after initial pulmonary manifestation was 269 ± 23 months and 5, 10 and 15 year survival rates were 91, 73 and 57%, respectively. Mean survival was 113 ± 5 months, and 5- and 10-year survival rates after the lung involvement detected with HRCT were 85 and 66%, respectively. Pulmonary artery hypertension, disease onset after the age of 40, and honeycombing on HRCT were associated with poor survival. Our data suggest that pulmonary involvement is the most important determinant factor for poor prognosis in patients with SSc. Therefore, echocardiography, pulmonary function tests, and HRCT should be performed in early stages of the disease for early diagnosis of pulmonary artery hypertension and lung involvement before irreversible vascular and interstitial changes exist.
Url:
DOI: 10.1007/s00296-011-1842-x
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 002686
- to stream Istex, to step Curation: 002686
- to stream Istex, to step Checkpoint: 000481
- to stream Main, to step Merge: 001507
- to stream Main, to step Curation: 001505
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Survival in progressive systemic sclerosis with pulmonary involvement: a single-center experience in Istanbul, Turkey</title><author><name sortKey="Zuhur, Ferit" sort="Zuhur, Ferit" uniqKey="Zuhur F" first="Ferit" last="Zuhur">Ferit Zuhur</name></author><author><name sortKey="Zuhur, Sayid Shafi" sort="Zuhur, Sayid Shafi" uniqKey="Zuhur S" first="Sayid Shafi" last="Zuhur">Sayid Shafi Zuhur</name></author><author><name sortKey="Zuhur, Cigdem" sort="Zuhur, Cigdem" uniqKey="Zuhur C" first="Cigdem" last="Zuhur">Cigdem Zuhur</name></author><author><name sortKey="Musellim, Benan" sort="Musellim, Benan" uniqKey="Musellim B" first="Benan" last="Musellim">Benan Musellim</name></author><author><name sortKey="Ongen, Gul" sort="Ongen, Gul" uniqKey="Ongen G" first="Gul" last="Ongen">Gul Ongen</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:D67A971CEA58177146A7EBBFFB4E48C7DC55D3BE</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1007/s00296-011-1842-x</idno><idno type="url">https://api.istex.fr/ark:/67375/VQC-1Q3L2BV0-G/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">002686</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002686</idno><idno type="wicri:Area/Istex/Curation">002686</idno><idno type="wicri:Area/Istex/Checkpoint">000481</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000481</idno><idno type="wicri:doubleKey">0172-8172:2011:Zuhur F:survival:in:progressive</idno><idno type="wicri:Area/Main/Merge">001507</idno><idno type="wicri:Area/Main/Curation">001505</idno><idno type="wicri:Area/Main/Exploration">001505</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Survival in progressive systemic sclerosis with pulmonary involvement: a single-center experience in Istanbul, Turkey</title><author><name sortKey="Zuhur, Ferit" sort="Zuhur, Ferit" uniqKey="Zuhur F" first="Ferit" last="Zuhur">Ferit Zuhur</name><affiliation wicri:level="1"><country xml:lang="fr">Turquie</country><wicri:regionArea>Department of Pulmonary Disease, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul</wicri:regionArea><wicri:noRegion>Istanbul</wicri:noRegion></affiliation><affiliation></affiliation></author><author><name sortKey="Zuhur, Sayid Shafi" sort="Zuhur, Sayid Shafi" uniqKey="Zuhur S" first="Sayid Shafi" last="Zuhur">Sayid Shafi Zuhur</name><affiliation wicri:level="1"><country xml:lang="fr">Turquie</country><wicri:regionArea>Department of Internal Medicine, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul</wicri:regionArea><wicri:noRegion>Istanbul</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Turquie</country><wicri:regionArea>Endocrinology and Metabolism Clinic, Sisli Etfal Training and Research Hospital, Istanbul</wicri:regionArea><wicri:noRegion>Istanbul</wicri:noRegion></affiliation></author><author><name sortKey="Zuhur, Cigdem" sort="Zuhur, Cigdem" uniqKey="Zuhur C" first="Cigdem" last="Zuhur">Cigdem Zuhur</name><affiliation wicri:level="1"><country xml:lang="fr">Turquie</country><wicri:regionArea>Department of Pulmonary Disease, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul</wicri:regionArea><wicri:noRegion>Istanbul</wicri:noRegion></affiliation></author><author><name sortKey="Musellim, Benan" sort="Musellim, Benan" uniqKey="Musellim B" first="Benan" last="Musellim">Benan Musellim</name><affiliation wicri:level="1"><country xml:lang="fr">Turquie</country><wicri:regionArea>Department of Pulmonary Disease, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul</wicri:regionArea><wicri:noRegion>Istanbul</wicri:noRegion></affiliation></author><author><name sortKey="Ongen, Gul" sort="Ongen, Gul" uniqKey="Ongen G" first="Gul" last="Ongen">Gul Ongen</name><affiliation wicri:level="1"><country xml:lang="fr">Turquie</country><wicri:regionArea>Department of Pulmonary Disease, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul</wicri:regionArea><wicri:noRegion>Istanbul</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Rheumatology International</title><title level="j" type="sub">Clinical and Experimental Investigations</title><title level="j" type="abbrev">Rheumatol Int</title><idno type="ISSN">0172-8172</idno><idno type="eISSN">1437-160X</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="2012-06-01">2012-06-01</date><biblScope unit="volume">32</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="1655">1655</biblScope><biblScope unit="page" to="1661">1661</biblScope></imprint><idno type="ISSN">0172-8172</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0172-8172</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>HRCT</term><term>Progressive systemic sclerosis</term><term>Pulmonary hypertension</term><term>Pulmonary involvement</term><term>Survival</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: The objective of the current study was to determine survival and factors that affect survival in progressive systemic sclerosis (SSc) with pulmonary involvement. A total of 102 SSc patients with pulmonary involvement, diagnosed between 1994 and 2008, enrolled into the study. Pulmonary involvement was defined based on the presence of interstitial changes on high-resolution CT (HRCT). Demographical, clinical, radiological, and laboratory data of the patients were found from patient records and were used for the evaluation of survival. The mean age of the patients at diagnosis was 50 ± 12 years. In follow-up, 22 (21.5%) patients were deceased. The mean age of the patients at death was 55 ± 12 years. Seventy-eight percent of known causes of mortality were related to pulmonary complications. After any initial systemic manifestation of disease, the mean survival was 447 ± 27 months and 5, 10, 15, and 20 year survival rates were 99, 92, 83, and 72%, respectively. The mean survival after initial pulmonary manifestation was 269 ± 23 months and 5, 10 and 15 year survival rates were 91, 73 and 57%, respectively. Mean survival was 113 ± 5 months, and 5- and 10-year survival rates after the lung involvement detected with HRCT were 85 and 66%, respectively. Pulmonary artery hypertension, disease onset after the age of 40, and honeycombing on HRCT were associated with poor survival. Our data suggest that pulmonary involvement is the most important determinant factor for poor prognosis in patients with SSc. Therefore, echocardiography, pulmonary function tests, and HRCT should be performed in early stages of the disease for early diagnosis of pulmonary artery hypertension and lung involvement before irreversible vascular and interstitial changes exist.</div></front></TEI><affiliations><list><country><li>Turquie</li></country></list><tree><country name="Turquie"><noRegion><name sortKey="Zuhur, Ferit" sort="Zuhur, Ferit" uniqKey="Zuhur F" first="Ferit" last="Zuhur">Ferit Zuhur</name></noRegion><name sortKey="Musellim, Benan" sort="Musellim, Benan" uniqKey="Musellim B" first="Benan" last="Musellim">Benan Musellim</name><name sortKey="Ongen, Gul" sort="Ongen, Gul" uniqKey="Ongen G" first="Gul" last="Ongen">Gul Ongen</name><name sortKey="Zuhur, Cigdem" sort="Zuhur, Cigdem" uniqKey="Zuhur C" first="Cigdem" last="Zuhur">Cigdem Zuhur</name><name sortKey="Zuhur, Sayid Shafi" sort="Zuhur, Sayid Shafi" uniqKey="Zuhur S" first="Sayid Shafi" last="Zuhur">Sayid Shafi Zuhur</name><name sortKey="Zuhur, Sayid Shafi" sort="Zuhur, Sayid Shafi" uniqKey="Zuhur S" first="Sayid Shafi" last="Zuhur">Sayid Shafi Zuhur</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001505 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001505 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:D67A971CEA58177146A7EBBFFB4E48C7DC55D3BE
|texte= Survival in progressive systemic sclerosis with pulmonary involvement: a single-center experience in Istanbul, Turkey
}}
| This area was generated with Dilib version V0.6.33. |  |